상품상세정보
의학서적전문 "성보의학서적"의 신간의학도서입니다.
Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders.
- Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field
- Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine
- Written at a verbal and technical level that can be understood by scientists and college students
- Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials
-도서목차-
1. Epigenetics OverviewSECTION I: Molecular Mechanisms of Epigenetics 2. Mechanisms of DNA Methylation and Demethylation during Mammalian Development 3. Mechanisms of Histone Modification 4. The Epigenetics of Non-coding RNA 5. Prions and Prion-like Phenomena in Epigenetic Inheritance 6. Higher-order Chromatin Organization in Diseases 7. Polycomb-group Proteins and Epigenetic Control of Gene Activity
SECTION II: Methods in Epigenetics 8. Methods for Assessing DNA Cytosine Modifications Genome-wide 9. Analyses of Genome-wide Histone Modifications in the Mammalian Genome 10. Techniques for Genome-wide Expression of Non-coding RNA 11. Computational Epigenetics
SECTION III: Model Organisms of Epigenetics 12. Epigenetics of Lower Organisms 13. Drosophila Epigenetics 14. Models of Mouse Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies 15. Plant Epigenomics
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ECTION IV: Factors Influencing Epigenetic Changes 16. Dynamic Changes in Epigenetic Modifications During Mammalian Transitions 17. Epigenetic Biomarkers 18. Transposable elements shaping the epigenome 19. Metabolic Regulation of DNA Methylation in Mammalian Cells 20. Dietary and Metabolic Compounds Affecting Covalent Histone Modifications 21. Epigenetics, Stem Cells and Cellular Differentiation 22. Regeneration Epigenetics 23. Epigenetics of X-chromosome Inactivation 24. Epigenetics of Memory Processes 25. Transgenerational Epigenetics 26. DNA Methylation Clocks in Age-related Disease
SECTION V: Evolutionary Epigenetics 27. Evolution of Epigenetic Mechanisms in Plants 28. Evolution of Epigenetic Mechanisms in Animals and Their Role in Speciation 29. Adaptive Evolution and Epigenetics
SECTION VI: Epigenetic Epidemiology 30. Epigenetics of Livestock Breeding 31. Nutritional Epigenetics and Metabolic Syndrome 32. Epigenetics of Drug Addiction 33. Environmental Influence of Epigenetics 34. The Gut Microbiota Influence on Human Epigenetics, Health and Disease 35. Population Pharmacoepigenomics
SECTION VII: Epigenetics and Human Disease 36. Cancer Epigenetics 37. The Role of Epigenetics in Autoimmune Disorders 38. Epigenetics of Brain Disorders 39. The Epigenetics of Metabolic Diseases 40. Imprinting Disorders in Humans
SECTION VIII: Epigenetic Therapy 41. DNA Demethylating Agents in Clinical Medicine 42. Clinical Applications of Histone Deacetylase Inhibitors 43. Combination Epigenetic Therapy
SECTION XI: The Future of Epigenetics 44. New Directions for Epigenetic Research: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research
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