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  • Principles of Virology (2 Vol Set),5/e

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    도서명: Principles of Virology (2 Vol Set),5/e
    정   가: 250,000원
    판매가: 225,000원
    적립금: 4,500원 (2%)
    저   자: Jane Flint
    출판사: Wiley
    ISBN  : 9781683670322
    출판일: 2020.11
    판   형: Softcover
    수량: 수량증가수량감소
    판   수: 5/e
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    의학서적전문 "성보의학서적"의 신간의학도서입니다.


    Principles of Virology, the leading virology textbook in use, is an extremely valuable and highly informative presentation of virology at the interface of modern cell biology and immunology. This text utilizes a uniquely rational approach by highlighting common principles and processes across all viruses. Using a set of representative viruses to illustrate the breadth of viral complexity, students are able to under-stand viral reproduction and pathogenesis and are equipped with the necessary tools for future encounters with new or understudied viruses.

    This fifth edition was updated to keep pace with the ever-changing field of virology. In addition to the beloved full-color illustrations, video interviews with leading scientists, movies, and links to exciting blogposts on relevant topics, this edition includes study questions and active learning puzzles in each chapter, as well as short descriptions regarding the key messages of references of special interest.

    Volume I: Molecular Biology focuses on the molecular processes of viral reproduction, from entry through release. Volume II: Pathogenesis and Control addresses the interplay between viruses and their host organisms, on both the micro- and macroscale, including chapters on public health, the immune response, vaccines and other antiviral strategies, viral evolution, and a brand new chapter on the therapeutic uses of viruses. These two volumes can be used for separate courses or together in a single course. Each includes a unique appendix, glossary, and links to internet resources.

    Principles of Virology, Fifth Edition, is ideal for teaching the strategies by which all viruses reproduce, spread within a host, and are maintained within populations. This edition carefully reflects the results of extensive vetting and feedback received from course instructors and students, making this renowned textbook even more appropriate for undergraduate and graduate courses in virology, microbiology, and infectious diseases.



    -도서목차-


    Volume 1
    Preface
    Acknowledgments
    About the Authors
    PART I: The Science of Virology
    1 Foundations
    Luria’s Credo
    Viruses Defined
    Why We Study Viruses
    Viruses Are Everywhere
    Viruses Infect All Living Things
    Viruses Can Cause Human Disease
    Viruses Can Be Beneficial
    Viruses “R” Us
    Viruses Can Cross Species Boundaries
    Viruses Are Unique Tools To Study Biology
    Virus Prehistory
    Viral Infections in Antiquity
    The First Vaccines Microorganisms as Pathogenic Agents
    Discovery of Viruses
    The Defining Properties of Viruses
    The Structural Simplicity of Virus Particles
    The Intracellular Parasitism of Viruses
    Cataloging Animal Viruses
    The Classical System
    Classification by Genome Type: the Baltimore System
    A Common Strategy for Viral Propagation
    Perspectives
    References
    Study Questions
    2 The Infectious Cycle
    Introduction
    The Infectious Cycle
    The Cell
    Entering Cells
    Viral RNA Synthesis
    Viral Protein Synthesis
    Viral Genome Replication
    Assembly of Progeny Virus Particles
    Viral Pathogenesis
    Overcoming Host Defenses
    Cultivation of Viruses
    Cell Culture
    Embryonated Eggs
    Laboratory Animals
    Assay of Viruses
    Measurement of Infectious Units
    Efficiency of Plating
    Measurement of Virus Particles
    Viral Reproduction: the Burst Concept
    The One-Step Growth Cycle
    One-Step Growth Analysis: a Valuable Tool for Studying Animal Viruses
    Global Analysis
    DNA Microarrays
    Mass Spectrometry
    Protein-Protein Interactions
    Single-Cell Virology
    Perspectives
    References
    Study Questions
    PART II: Molecular Biology
    3 Genomes and Genetics
    Introduction
    Genome Principles and the Baltimore System
    Structure and Complexity of Viral Genomes
    DNA Genomes
    RNA Genomes
    What Do Viral Genomes Look Like?
    Coding Strategies
    What Can Viral Sequences Tell Us?\The “Big and Small” of Viral Genomes: Does Size Matter?
    The Origin of Viral Genomes
    Genetic Analysis of Viruses
    Classical Genetic Methods
    Engineering Mutations into Viral Genomes
    Engineering Viral Genomes: Viral Vectors
    Perspectives
    References
    Study Questions
    4 Structure
    Introduction
    Functions of the Virion
    Nomenclature
    Methods for Studying Virus Structure
    Building a Protective Coat
    Helical Structures
    Capsids with Icosahedral Symmetry
    Other Capsid Architectures
    Packaging the Nucleic Acid Genome
    Direct Contact of the Genome with a Protein Shell
    Packaging by Specialized Viral Proteins
    Packaging by Cellular Proteins
    Viruses with Envelopes
    Viral Envelope Components
    Simple Enveloped Viruses: Direct Contact of External Proteins with the Capsid or Nucleocapsid
    Enveloped Viruses with an Additional Protein Layer
    Large Viruses with Multiple
    Structural Elements Particles with Helical or Icosahedral Parts Alternative Architectures
    Other Components of Virions
    Enzymes
    Other Viral Proteins
    Cellular Macromolecules
    Mechanical Properties of Virus Particles
    Investigation of Mechanical Properties of Virus Particles
    Stabilization and Destabilization of Virus Particles
    Perspectives
    References
    Study Questions
    5 Attachment and Entry
    Introduction
    Attachment of Virus Particles to Cells
    General Principles
    Identification of Receptors for Virus Particles
    Virus-Receptor Interactions
    Entry into Cells
    Virus-induced Signaling via Cell Receptors
    Routes of entry
    Membrane Fusion
    Intracellular Trafficking and Uncoating
    Movement of Viral and Subviral Particles within Cells
    Uncoating of enveloped viruses
    Uncoating of non-enveloped viruses
    Import of Viral Genomes into the Nucleus
    The Nuclear Pore Complex
    Nuclear Localization Signals
    Import of RNA Genomes
    Import of DNA Genomes
    Import of Retroviral Genomes
    Perspectives
    References
    Study Questions
    6 Synthesis of RNA from RNA Templates
    Introduction
    The Nature of the RNA Template
    Secondary Structures in Viral RNA
    Naked or Nucleocapsid RNA
    The RNA Synthesis Machinery
    Identification of RNA-Dependent RNA Polymerases
    Three-Dimensional Structures of RNA-Dependent RNA Polymerases
    Mechanisms of RNA Synthesis
    Initiation
    Capping
    Elongation
    Functions of Additional Polymerase Domains
    RNA polymerase Oligomerization
    Template Specificity
    Unwinding the RNA Template
    Role of Cellular Proteins
    Paradigms for Viral RNA Synthesis
    (+) Strand RNA
    Synthesis of Nested Subgenomic mRNAs
    (−) Strand RNA
    Ambisense RNA
    Double-Stranded RNA
    Unique Mechanisms of mRNA and Genome Synthesis of Hepatitis Delta Satellite Virus
    Do Ribosomes and RNA Polymerases Collide?
    Origins of Diversity in RNA Virus Genomes
    Misincorporation of Nucleotides
    Segment Reassortment and RNA Recombination
    RNA Editing
    Perspectives
    References
    Study Questions
    7 Synthesis of RNA from DNA Templates
    Introduction
    Properties of Cellular RNA Polymerases That Transcribe Viral DNA
    Some Viral Genomes Must Be Converted to Templates Suitable for Transcription
    Transcription by RNA Polymerase II
    Regulation of RNA Polymerase II Transcription
    Common Properties of Proteins That Regulate Transcription
    Transcription of Viral DNA Templates by the Cellular Machinery Alone
    Viral Proteins That Govern Transcription of DNA Templates
    Patterns of Regulation
    The Human Immunodeficiency Virus Type 1 Tat Protein Autoregulates Transcription
    The Transcriptional Cascades of DNA Viruses
    Entry into One of Two Alternative Transcriptional Programs
    Transcription of Viral Genes by RNA Polymerase III
    The VA-RNA I Promoter
    Inhibition of the Cellular Transcriptional Machinery
    Unusual Functions of Cellular Transcription Components in Virus-Infected Cells
    Viral DNA-Dependent RNA Polymerases
    Perspectives
    References
    Study Questions
    8 Processing
    Introduction
    Covalent Modification during Viral Pre-mRNA Processing
    Capping the 5′ Ends of Viral mRNA
    Synthesis of 3′ Poly(A) Segments of Viral mRNA
    Internal Methylation of Adenosine Residues
    Splicing of Viral Pre-mRNA
    Regulated Processing of Viral Pre-mRNA
    Editing of Viral mRNAs
    Export of RNAs from the Nucleus
    The Cellular Export Machinery Export of Viral mRNA
    Posttranscriptional Regulation of Viral or Cellular Gene Expression by Viral Proteins
    Temporal Control of Viral Gene Expression
    Viral Proteins Can Inhibit Cellular mRNA Production
    Regulation of Turnover of Viral and Cellular mRNAs in the Cytoplasm
    Intrinsic Turnover
    Regulation of mRNA Stability by Viral Proteins
    mRNA Stabilization Can Facilitate Transformation
    Nonsense-Mediated mRNA Decay
    Noncoding RNAs
    Small Interfering RNAs and Micro-RNAs
    Long Noncoding RNAs
    Circular RNAs
    Perspectives
    References
    Study Questions
    9 Replication of DNA Genomes
    Introduction
    DNA Synthesis by the Cellular Replication Machinery
    Eukaryotic Replicons
    Cellular Replication Proteins
    Mechanisms of Viral DNA Synthesis
    Lessons from Simian Virus 40
    Replication of Other Viral DNA Genomes
    Properties of Viral Replication Origins
    Recognition of Viral Replication Origins
    Viral DNA Synthesis Machines
    Resolution and Processing of Viral Replication Products
    Exponential Accumulation of Viral Genomes
    Viral Proteins Can Induce Synthesis of Cellular Replication Proteins
    Synthesis of Viral Replication Machines and Accessory Enzymes
    Viral DNA Replication Independent of Cellular Proteins
    Delayed Synthesis of Structural Proteins Prevents Premature Packaging of DNA Templates
    Inhibition of Cellular DNA Synthesis
    Synthesis of Viral DNA in Specialized Intracellular Compartments
    Limited Replication of Viral DNA Genomes
    Integrated Parvoviral DNA Can Be Replicated as Part of the Cellular Genome
    Different Viral Origins Regulate Replication of Epstein-Barr Virus
    Limited and Amplifying Replication from a Single Origin: the Papillomaviruses
    Origins of Genetic Diversity in DNA Viruses
    Fidelity of Replication by Viral DNA Polymerases
    Modulation of the DNA Damage Response
    Recombination of Viral Genomes
    Perspectives
    References
    Study Questions
    10 Reverse Transcription and Integration
    Retroviral Reverse Transcription
    Discovery
    Impact
    The Process of Reverse Transcription
    General Properties and Structure of Retroviral Reverse Transcriptases
    Other Examples of Reverse Transcription
    Retroviral DNA Integration
    The Pathway of Integration: Integrase-Catalyzed Steps
    Integrase Structure and Mechanism
    Hepadnaviral Reverse Transcription
    A DNA Virus with Reverse Transcriptase
    The Process of Hepadnaviral Reverse Transcription
    Perspectives
    References
    Study Questions
    11 Protein Synthesis
    Introduction
    Mechanisms of Eukaryotic Protein Synthesis
    General Structure of Eukaryotic mRNA
    The Translation Machinery
    Initiation
    Elongation and Termination
    The Diversity of Viral Translation Strategies
    Polyprotein Synthesis
    Leaky Scanning
    Reinitiation
    StopGo Translation
    Suppression of Termination
    Ribosomal Frameshifting
    Bicistronic mRNAs
    Regulation of Translation during Viral Infection
    Inhibition of Translation Initiation after Viral Infection
    Regulation of eIF4F
    Regulation of Poly(A)-Binding Protein Activity
    Regulation of eIF3
    Interfering with RNA
    Stress-Associated RNA Granules
    Perspectives
    References
    Study Questions
    12 Intracellular Trafficking
    Introduction
    Assembly within the Nucleus
    Import of Viral Proteins for Assembly
    Assembly at the Plasma Membrane
    Transport of Viral Membrane Proteins to the Plasma Membrane
    Sorting of Viral Proteins in Polarized Cells
    Disruption of the Secretory Pathway in Virus-Infected Cells
    Signal Sequence-Independent Transport of Viral Proteins to the Plasma Membrane
    Interactions with Internal Cellular Membranes
    Localization of Viral Proteins to Compartments of the Secretory Pathway
    Localization of Viral Proteins to the Nuclear Membrane
    Transport of Viral Genomes to Assembly Sites
    Transport of Genomic and Pregenomic RNA from the Nucleus to the Cytoplasm
    Transport of Genomes from the Cytoplasm to the Plasma Membrane
    Perspectives
    References
    Study Questions
    13 Assembly, Release, and Maturation
    Introduction
    Methods of Studying Virus Assembly and Egress
    Structural Studies of Virus Particles
    Visualization of Assembly and Exit by Microscopy
    Biochemical and Genetic Analyses of Assembly Intermediates
    Methods Based on Recombinant DNA Technology
    Assembly of Protein Shells
    Formation of Structural Units
    Capsid and Nucleocapsid Assembly
    Self-Assembly and Assisted Assembly Reactions
    Selective Packaging of the Viral Genome and Other Components of Virus Particles
    Concerted or Sequential Assembly
    Recognition and Packaging of the Nucleic Acid
    GenomeIncorporation of Enzymes and Other Nonstructural Proteins
    Acquisition of an Envelope
    Sequential Assembly of Internal Components and Budding from a Cellular Membrane
    Coordination of the Assembly of Internal Structures with Acquisition of the Envelope
    Release of Virus Particles
    Assembly and Budding at the Plasma Membrane
    Assembly at Internal Membranes: the Problem of Exocytosis
    Release of Nonenveloped Virus Particles
    Maturation of Progeny Virus Particles
    Proteolytic Processing of Structural Proteins
    Other Maturation Reactions
    Cell-to-Cell Spread
    Perspectives
    References
    Study Questions
    14 The Infected Cell
    Introduction
    Signal Transduction
    Signaling Pathways
    Signaling in Virus-Infected Cells
    Gene Expression
    Inhibition of Cellular Gene Expression
    Differential Regulation of Cellular Gene Expression
    Metabolism
    Methods To Study Metabolism
    Glucose Metabolism
    The Citric Acid Cycle
    Electron Transport and Oxidative Phosphorylation
    Lipid MetabolismRemodeling of Cellular Organelles
    The Nucleus
    The Cytoplasm
    Perspectives
    References
    Study Questions
    APPENDIX Structure, Genome Organization, and Infectious Cycles of Viruses Featured in this Book
    Glossary
    Index
    Volume 2
    Preface
    Acknowledgments
    About the Authors
    1 Infections of Populations: History and Epidemiology
    Introduction to Viral Pathogenesis
    A Brief History of Viral Pathogenesis
    The Relationships among Microbes and the Diseases They Cause
    The First Human Viruses Identified and the Role of Serendipity
    New Methods Facilitate the Study of Viruses as Causes of Disease
    Viral Epidemics in History
    Epidemics Shaped History: the 1793 Yellow Fever Epidemic in Philadelphia
    Tracking Epidemics by Sequencing: West Nile Virus Spread to the Western Hemisphere
    Zoonotic Infections and Epidemics Caused by “New” Viruses
    The Economic Toll of Viral Epidemics in Livestock
    Population Density and World Travel Are Accelerators of Viral Transmission
    Focus on Frontline Health Care: Ebolavirus in Africa
    Emergence of a Birth Defect Associated with Infection: Zika Virus in Brazil
    Epidemiology
    Fundamental Concepts
    Methods Used by Epidemiologists
    Surveillance
    Network Theory and Practical Applications
    Parameters That Govern the Ability of a Virus to Infect a Population
    Geography and Population Density
    Climate
    Perspectives
    References
    Study Questions
    2 Barriers to Infection
    Introduction
    An Overview of Infection and Immunity
    A Game of Chess Played by Masters
    Initiating an Infection
    Successful Infections Must Modulate or Bypass Host Defenses
    Skin
    Respiratory Tract
    Alimentary Tract
    Eyes
    Urogenital Tract
    Placenta
    Viral Tropism
    Accessibility of Viral Receptors
    Other Host-Virus Interactions That Regulate the Infectious Cycle
    Spread throughout the Host
    Hematogenous Spread
    Neural Spread
    Organ Invasion
    Entry into Organs with Sinusoids
    Entry into Organs That Lack Sinusoids
    Organs with Dense Basement Membranes
    Skin
    Shedding of Virus Particles
    Respiratory Secretions
    Saliva
    Feces
    Blood
    Urine
    Semen
    Milk
    Skin Lesions
    Tears
    Perspectives
    References
    Study Questions
    3 The Early Host Response: Cell Autonomous and Innate Immunity
    Introduction
    The First Critical Moments: How Do Individual Cells Detect a Virus Infection?
    Cell Signaling Induced by Viral Entry Receptor Engagement
    Receptor-Mediated Recognition of Microbe-Associated Molecular Patterns
    Cell Intrinsic Defenses
    Apoptosis (Programmed Cell Death)
    Necroptosis and Other Cell Death Pathways
    Autophagy
    Epigenetic Silencing
    Cellular Restriction Factors
    RNA Interference
    CRISPR
    The Continuum Between Intrinsic and Innate Immunity
    Secreted Immune Mediators of the Innate Immune Response
    Overview of Cytokine Functions
    Interferons, Cytokines of Early Warning and Action
    Chemokines
    The Innate Immune Response
    Monocytes/macrophages
    Complement
    Natural Killer Cells
    Innate Lymphoid Cells
    Other Innate Immune Cells of Relevance to Viral Infections
    Perspectives
    References
    Study Questions
    4 Adaptive Immunity and the Establishment of Memory
    Introduction
    Attributes of the Host Response
    Speed
    Diversity and Specificity
    Memory
    Self-Control
    Lymphocyte Development, Diversity, and Activation
    The Hematopoietic Stem Cell Lineage
    The Two Arms of Adaptive Immunity
    The Major Effectors of the Adaptive Response: B and T Cells
    Diverse Receptors Impart Antigen Specificity to B and T Cells
    Events at the Site of Infection Set the Stage for the Adaptive Response
    Acquisition of Viral Proteins by Professional Antigen-Presenting Cells Enables Production of Proinflammatory Cytokines and Establishment of Inflammation
    Activated Antigen-Presenting Cells Leave the Site of Infection and Migrate to Lymph Nodes
    Antigen Processing and Presentation
    Professional Antigen-Presenting Cells Induce Activation via Costimulation
    Presentation of Antigens by Class I and Class II MHC Proteins
    Lymphocyte Activation Triggers Massive Cell Proliferation
    The CTL (Cell-Mediated) Response
    CTLs Lyse Virus-Infected Cells
    Control of CTL Proliferation
    Control of Infection by T Cells without Killing
    Rashes and Poxes
    The Humoral (Antibody) Response
    Antibodies Are Made by Plasma Cells
    Types and Functions of Antibodies
    Virus Neutralization by Antibodies
    Antibody-Dependent Cell-Mediated Cytotoxicity: Specific Killing by Nonspecific Cells
    Immunological Memory
    Perspectives
    References
    Study Questions
    5 Patterns and Pathogenesis
    Introduction
    Animal Models of Human Diseases
    Patterns of Infection
    Incubation Periods
    Mathematics of Growth Correlate with Patterns of Infection
    Acute Infections
    Persistent Infections
    Latent Infections
    Abortive Infections
    Transforming Infections
    Viral Virulence
    Measuring Viral Virulence
    Alteration of Viral Virulence
    Viral Virulence Genes
    Pathogenesis
    Infected Cell Lysis
    Immunopathology
    Immunosuppression Induced by Viral Infection
    Oncogenesis
    Molecular Mimicry
    Perspectives
    References
    Study Questions
    6 Cellular Transformation and Oncogenesis
    Introduction
    Properties of Transformed Cells
    Control of Cell Proliferation
    Oncogenic Viruses
    Discovery of Oncogenic Viruses
    iral Genetic Information in Transformed Cells
    The Origin and Nature of Viral Transforming Genes
    Functions of Viral Transforming Proteins
    Activation of Cellular Signal Transduction Pathways by Viral Transforming Proteins
    Viral Signaling Molecules Acquired from the Cell
    Alteration of the Production or Activity of Cellular Signal Transduction Proteins
    Disruption of Cell Cycle Control Pathways by Viral Transforming Proteins
    Abrogation of Restriction Point Control Exerted by the RB Protein
    Production of Virus-Specific Cyclins
    Inactivation of Cyclin-Dependent Kinase Inhibitors
    Transformed Cells Increase in Size and Survive
    Mechanisms That Permit Survival of Transformed Cells
    Tumorigenesis Requires Additional Changes in the Properties of Transformed Cells
    Inhibition of Immune Defenses
    Other Mechanisms of Transformation and Oncogenesis by Human Tumor Viruses
    Nontransducing Oncogenic Retroviruses: Tumorigenesis with Very Long Latency
    Oncogenesis by Hepatitis Viruses
    Perspectives
    References
    Study Questions
    7 Vaccines
    Introduction
    The Origins of Vaccination
    Smallpox: a Historical Perspective
    Worldwide Vaccination Programs Can Be Dramatically Effective
    Vaccine Basics
    Immunization Can Be Active or Passive
    Active Vaccination Strategies Stimulate Immune Memory
    The Fundamental Challenge
    The Science and Art of Making Vaccines
    Inactivated Virus Vaccines
    Attenuated Virus Vaccines
    Subunit Vaccines
    Virus-Like Particles
    Nucleic Acid Vaccines
    Vaccine Technology: Delivery and Improving Antigenicity
    Adjuvants Stimulate an Immune Response
    Delivery and Formulation
    Immunotherapy
    The Ongoing Quest for an AIDS Vaccine
    Perspectives
    References
    Study Question Puzzle
    8 Antiviral Drugs
    Introduction
    A Brief History of Antiviral Drug Discovery
    Discovering Antiviral Compounds
    The Lexicon of Antiviral Discovery
    Screening for Antiviral Compounds
    Computational Approaches to Drug Discovery
    The Difference between “R” and “D”
    Drug Resistance
    Examples of Antiviral Drugs
    Inhibitors of Virus Attachment and Entry
    Inhibitors of Viral Nucleic Acid Synthesis
    Inhibition of Viral Polyprotein Processing and Assembly
    Inhibition of Virus Particle Release
    Expanding Targets for Antiviral Drug Development
    Attachment and Entry Inhibitors
    Nucleic Acid-Based Approaches
    Proteases and Nucleic Acid Synthesis and Processing Enzymes
    Virus Particle Assembly
    Microbicides
    Two Stories of Antiviral Success
    Combination Therapy
    Challenges Remaining
    Perspectives
    References
    Study Questions
    9 Therapeutic Viruses
    Introduction
    Phage Therapy
    History
    Some Advantages and Limitations of Phage Therapy
    Applications in the Clinic and for Disease Prevention
    Future Prospects
    Oncolytic Animal VirusesFrom
    Anecdotal Reports to Controlled Clinical Trials
    Rational Design of Oncolytic Viruses
    Two Clinically Approved Oncolytic Viruses
    Future Directions
    Gene Therapy
    Introduction
    Retroviral Vectors
    Adenovirus-Associated Virus Vectors
    Future Prospects
    Vaccine Vectors
    DNA Viruses
    RNA Viruses
    Perspectives
    References
    Study Questions
    10 Virus Evolution
    Virus Evolution
    How Do Virus Populations Evolve?
    Two General Virus Survival Strategies Can Be Distinguished
    Large Numbers of Viral Progeny and Mutants Are Produced in Infected Cells
    The Quasispecies Concept
    Genetic Shift and Genetic Drift
    Fundamental Properties of Viruses That Constrain Evolution
    Two General Pathways for Virus Evolution
    Evolution of Virulence
    The Origin of Viruses
    When and How Did They Arise?
    Evolution of Contemporary Eukaryotic Viruses
    Host-Virus Relationships Drive Evolution
    DNA Virus-Host Relationships
    RNA Virus-Host Relationships
    The Host-Virus “Arms Race”
    Lessons from Paleovirology
    Endogenous Retroviruses
    DNA Fossils Derived from Other RNA Viral Genomes
    Endogenous Sequences from DNA Viruses
    Short- versus Long-Term Rates of Viral Evolution
    Perspectives
    References
    Study Questions
    11 Emergence
    The Spectrum of Host-Virus Interactions
    Stable Interactions
    The Evolving Host-Virus Interaction
    The Dead-End Interaction
    The Resistant Host
    Encountering New Hosts: Humans Constantly Provide New Venues for Infection
    Common Sources for Animal-to-Human Transmission
    Viral Diseases That Illustrate the Drivers of Emergence
    Poliomyelitis: Unexpected Consequences of Modern Sanitation
    Introduction of Viruses into Naïve Populations
    Hantavirus Pulmonary Syndrome: Changing Animal Populations
    Severe Acute and Middle East Respiratory Syndromes (SARS and MERS): Zoonotic Coronavirus Infections
    The Contribution to Emergence of Mutation, Recombination, or Reassortment
    Canine Parvoviruses: Cat-to-Dog Host Range Switch by Two Amino Acid Changes
    Influenza Epidemics and Pandemics: Escaping the Immune Response by Reassortment
    New Technologies Uncover Previously Unrecognized Viruses
    Hepatitis Viruses in the Human Blood Supply
    A Revolution in Virus Discovery
    Perceptions and Possibilities
    Virus Names Can Be Misleading
    All Viruses Are Important
    Can We Predict the Next Viral Pandemic?
    Preventing Emerging Virus Infections
    Perspectives
    References
    Study Questions
    12 Human Immunodeficiency Virus Type I Pathogenesis
    Introduction
    Worldwide Impact of AIDS
    HIV-1 Is a Lentivirus
    Discovery and Characterization
    Distinctive Features of the HIV-1 Reproduction Cycle and the Functions of HIV-1 Proteins
    The Viral Capsid Counters Intrinsic Defense Mechanisms
    Entry and Transmission
    Entry in the Cell
    Entry into the Body
    Transmissions in Human Populations
    The Course of Infection
    The Acute Phase
    The Asymptomatic Phase
    The Symptomatic Phase and AIDS
    Effects of HIV-1 on Other Tissues and Organs
    Virus Reproduction
    Dynamics in the Absence of Treatment
    Dynamics of Virus Reproduction during Treatment
    Latency
    Immune Responses to HIV-1
    Innate Response
    Humoral Responses
    HIV-1 and Cancer
    Kaposi’s Sarcoma
    B-Cell Lymphomas
    Anogenital Carcinomas
    Prospects for Treatment and Prevention
    Antiviral Drugs
    Confronting the Problems of Persistence and Latency
    Gene Therapy Approaches
    Immune System-Based Therapies
    Antiviral Drug Prophylaxis
    Perspectives
    References
    13 Unusual Infectious Agents
    Introduction
    Viroids
    Replication
    Sequence Diversity
    Movement
    Pathogenesis
    Satellite Viruses and RNAs
    Replication
    Pathogenesis
    Hepatitis Delta Virus
    Prions and Transmissible Spongiform Encephalopathies
    Scrapie
    Physical Properties of the Scrapie Agent
    Human TSEs
    Hallmarks of TSE Pathogenesis
    Prions and the prnp Gene
    Prion Strains
    Bovine Spongiform Encephalopathy
    Chronic Wasting Disease
    Treatment of Prion Diseases
    Perspectives
    References
    Study Questions
    APPENDIX Epidemiology and Pathogenesis of Selected Human Viruses
    Glossary
    Index



    기타 의학도서에  관련된 문의사항은 고객센터(02-854-2738) 또는 저희 성보의학서적 홈페이지내 도서문의 게시판에 문의바랍니다.
    감사합니다.
    성보의학서적 "http://www.medcore.kr

    상품결제정보

    고액결제의 경우 안전을 위해 카드사에서 확인전화를 드릴 수도 있습니다.

    확인과정에서 도난 카드의 사용이나 타인 명의의 주문등 정상적인 주문이 아니라고 판단될 경우 임의로 주문을 보류 또는 취소할 수 있습니다.  

    무통장 입금은 상품 구매 대금은 PC뱅킹, 인터넷뱅킹, 텔레뱅킹 혹은 가까운 은행에서 직접 입금하시면 됩니다.  
    주문시 입력한 입금자명과 실제입금자의 성명이 반드시 일치하여야 하며, 3일 이내로 입금을 하셔야 하며 입금되지 않은 주문은 자동취소 됩니다.

    배송정보

    • 배송 방법 : 택배
    • 배송 지역 : 전국지역
    • 배송 비용 : 2,500원
    • 배송 기간 : 3일 ~ 5일
    • 배송 안내 :


    • 고객님께서 저희 성보의학서적에서 주문을 하신 주문번호가 생성이 되면 그에 따른 발송준비 및 배송절차는 다음과 같습니다

      - 일반적으로 배송기간은 입금확인일로부터 3일 이내 배송을 원칙으로 합니다. 이는 재고가 확보된 도서의 경우입니다.
      (단, 산간이나 지방 및 도서지역의 경우 약 1~2일이 더 소요될 수 있습니다.)
      - 배송의 시점은 고객님의 주문 이후 입금확인 과정을 거쳐 배송이 됩니다.
      - 주문도서의 배송 시 휴일이 포함된 경우는 24시간 순연됩니다.
      - 배송료는 회원주문, 비회원주문 모두 2,500원 입니다. (일부 도서 및 산간지역은 추가 배송비 발생)
      - 주문 금액이 30,000원 이상일 경우에는 무료로 배송해 드립니다.
      - 반품/취소.환불 시 배송비는 무료로 배송이 되었을 경우, 처음 발생한 배송비까지 소급 적용될 수 있으며,
      상품 하자로 인한 도서 교환시에는 무료로 가능합니다.
      - 성보의학서적의 기본배송방법으로 택배서비스(한진택배&우체국)를 이용합니다.


      해외원서의 경우
      - 국내에서 재고를 보유한 업체가 없는 경우 해외주문을 해야 하는 상황이 생깁니다.
      이 경우 4~5주 안에 공급이 가능하며 현지 출판사 사정에 따라 구입이 어려운 경우 2~3주 안에 공지해 드립니다.
      - 재고 유무는 주문 전 사이트 상에서 배송 안내 문구로 구분 가능하며, 필요에 따라 전화 문의 주시면 거래처를 통해
      다시 한번 국내재고를 확인해 드립니다.

      - 해외 주문 도서는 고객님의 요청에 의해 주문하는 '개인주문' 상품으로, 단순한 고객변심/착오로 인한 취소, 교환, 반품은 불가능합니다.
      - 해외주문 시 도서가격 및 수입 제반 비용 등을 모두 선결제로 진행하고 재고 관련 등의 사유로 취소, 교환, 반품이 불가능하오니
      이점 꼭 숙지하시고 해외주문시 신중하게 주문하여 주시기 바랍니다.

    교환 및 반품정보

    반품안내
    전자상거래에 의한 소비자보호에 관한 법률에 의거 반품 가능 기간내에는 반품을 요청하실 수 있습니다.

    반품가능기간
    - 단순변심 : 물품 수령 후 14일 이내 (단, 고객님의 요청으로 주문된 해외원서 제외)


    - 주문하신 것과 다른 상품을 받으신 경우

    - 파본인 상품을 받으신 경우
    - 배송과정에서 손상된 상품을 받으신 경우



    - 개봉된 DVD, CD-ROM, 카세트테이프 (단, 배송 중 파손된 상품 제외)

    - 탐독의 흔적이 있는 경우
    - 소비자의 실수로 상품이 훼손된 경우
    - 고객님의 주문으로 수입된 해외 도서인 경우
    - 수령일로 14일 지난 상품의 경우

    - 해외 주문 도서는 고객님의 요청에 의해 주문하는 '개인주문' 상품으로, 단순한 고객변심/착오로 인한 취소, 교환, 반품은 불가능합니다.
    - 해외주문 시 도서가격 및 수입 제반 비용 등을 모두 선결제로 진행하고 재고 관련 등의 사유로 취소, 교환, 반품이 불가능하오니
      이점 꼭 숙지하시고 해외주문시 신중하게 주문하여 주시기 바랍니다.


    반품절차
    - 배송완료후 3일 이내에 고객센터 02-854-2738 혹은 1:1 문의게시판을 통해 교환 및 반품 의사를 알려주세요.
    - 도서는 택배 또는 등기우편으로 보내주시기 바랍니다.
    - 14일 이내에 교환/반품/환불 받으실 상품이 회수되어야 하며, 반품과 환불의 경우 상품주문시 면제받으셨던
      배송비와 반품배송비까지 고객님께서 부담하시게 됩니다.

    반품주소
    (10881) 서울시 구로구 구로중앙로26길 32(구로동) 1층(성보의학서적)
    전화) 02-854-2738

    환불방법
    - 대금은 반품 확인 후에, 카드취소/ 적립금 지급/ 계좌로 환불조치 해 드립니다.
    - 카드결제 시 카드 승인취소절차를 밟게 되며 무통장입금시 현금 환불 혹은 적립금으로 변환 가능합니다.
    - 반품도서와 함께 도서명, 주문번호와 환불계좌번호를 알려주시면 빠른 처리 가능합니다.



    서비스문의

    성보의학서적(Medical Book Store) 전화: 02) 854-2738 팩스: 02) 854-2808 이메일: medcore15@naver.com

    고객센터: (02)854-2738

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