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의학서적전문 "성보의학서적"의 신간의학도서입니다.
Extensively revised, comprehensive content from leading global contributors ensures that Hematology, 8th Edition, remains your #1 choice for expert guidance in all areas of this rapidly advancing subspecialty. This edition reflects the numerous advances that are redefining the field and dramatically influencing new approaches to diagnosis, treatment, and outcomes. Well-illustrated and clinically focused, it details the basic science and clinical practice of hematology and hematopoietic cellular therapy—covering virtually all aspects of hematology in one definitive resource.
Key FeaturesCovers all hematologic disorders, including comprehensive discussions of hematologic malignancies, individualized patient care, cell-based therapies, transplantation, transfusion medicine, hemostasis, thrombosis, and consultative hematology—in one convenient volume.
Provides state-of-the-art guidance from global experts at the forefront of the latest research and clinical practice.
Provides extensive updates throughout on basic science research, advances in molecular diagnostics, new drugs, immunotherapies, personalized medicine, laboratory medicine, transfusion medicine, stem cell transplantation, and clinical treatment for all hematologic malignancies and non-malignancies
Contains new chapters on gene editing; the impact of mitochondria on hematopoiesis; myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes; immunotherapy and management of its toxicities; transfusion medicine in sickle cell disease; principles of radiation therapy; and COVID-19, including complications of vaccination and its impact on the hematologic system.
Discusses many new advances in the field, including details and the future of gene therapy for hemophilia, gene editing for sickle cell disease and thalassemia, the evolution of cellular therapy, use of cells, transfusion medicine vs. protein therapy, gene sequencing, immunotherapy, and new targeted drugs.
Includes more decision-making algorithms for formulating diagnoses and personalized treatment plans for those highly complex disorders that require individualized approaches.
Addresses the effects of aging on hematopoiesis and on the manifestations of a variety of hematologic disorders.
Discusses cardio-oncology and its impact on the treatment of patients with hematologic disorders.
Presents relevant basic science as background for clinical application in later sections.
An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Author InformationEdited by Ronald Hoffman, MD, Albert A. and Vera G. List Professor of Medicine, Tisch Cancer Institute, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York ; Edward J. Benz, Jr., MD, Richard and Susan Smith Professor of Medicine, Professor of Pediatrics and Genetics, Harvard Medical School; President and CEO, Dana-Farber Cancer Institute Director and Principal Investigator Dana Farber/Harvard Cancer Center, Boston, Massachusetts; Leslie E. Silberstein, MD, Director, Transfusion Medicine, Professor of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachussetts ; Helen Heslop, MD, Professor, Departments of Medicine and Pediatrics Section of Hematology-Oncology, Baylor College of Medicine; Dan L. Duncan Chair Director, Adult Stem Cell Transplant Program, The Methodist Hospital; Associate Director Clinical Research, Dan L. Duncan Cancer Center; Houston, Texas; Jeffrey Weitz, MD, Professor of Medicine and Biochemistry and Biomedical Sciences, McMaster University, Heart and Stroke Foundation/J.F. Mustard Chair in Cardiovascular Research Canada Research Chair (Tier 1) in Thrombosis, Executive Director, Thrombosis & Atherosclerosis Research Institute (TaARI), Hamilton General Hospital, Hamilton, Ontario, Canada ; Mohamed E. Salama, MD and Syed Ali Abutalib
-도서목차-Part I. MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY
Chapter 1 Anatomy and Physiology of the Gene
Edward J. Benz, Jr., Andrew Wagner, Nancy Berliner
Chapter 2 Genomic Approaches to the Study of Hematologic Science
Todd Golub and Scott Armstrong
Chapter 3 Protein Synthesis, Processing, and Degradation
Garabet G. Toby and David L. Wiest
Chapter 4 Protein Architecture: Relationship of Form and Function
Alan C. Rigby and Barbara C. Furie
Chapter 5 Regulation of Cellular Response
Benjamin G. Neel and Christopher Carpenter
Chapter 6 Cell Adhesion
Rodger P. McEver
Chapter 7 Control of Cell Division
William M.F. Lee and Chi V. Dang
Chapter 8 Cell Death
David M. Hockenbery and Stanley J. Korsmeyer
Chapter 9 Pharmacogenomics and Hematological Diseases
Loe Kager and William E. Evans
Part II. IMMUNOLOGIC BASIS OF HEMATOLOGY
Chapter 10 Overview and Compartmentalization of the Immune System
Leland D. Powell and Linda G. Baum
Chapter 11 B-Cell Development
Kenneth Dorshkind and David J. Rawlings
Chapter 12 T-Cell and NK-Cell Immunity
Carol Clayberger and Alan M. Krensky
Chapter 13 Dendritic Cell Biology
Zbigniew M. Szczepiorkowski and Nina Bhardwhaj
Chapter 14 Regulation of Activation of B and I Lymphocytes
John C. Monroe and Lawrence Turka
Chapter 15 Leukocyte Trafficking
James J. Campbell, Steven Sloan, and Leslie E. Silberstein
Chapter 16 Tolerance and Autoimmunity
Mark J. Shlomchik
Part III. BIOLOGY OF STEM CELLS AND DISORDERS OF HEMATOPOIESIS
Chapter 17 Stem Cell Model of Hematopoiesis
Anskar YH Leung and Catherine M. Verafaillie
Chapter 18 Bone Marrow Microenvironment
Mo Dao and Catherine M. Verfaillie
Chapter 19 The Humeral Regulation of Hematopoiesis
Montaser Shaheen and Hal Broxmeyer
Chapter 20 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
Thalia Papayannopoulou, Alan D’Andrea, Janis Abkowitz, and Anna Rita Migliaccio
Chapter 21 Granulopoiesis and Monocytopoiesis
Arati Khanna-Gupta and Nancy Berliner
Chapter 22 Thrombocytopoiesis
Michael W. Long and Ronald Hoffman
Chapter 23 Thrombocytopenia Due to Decreased Platelet Production
J. B. Opalinska and Alan M. Gewirtz
Chapter 24 Inherited Forms of Bone Marrow Failure
Melvin H. Freedman
Chapter 25 Aplastic Anemia
Neal S. Young and Jaroslaw P. Maciejewski
Chapter 26 Paroxysmal Nocturnal Hemoglobinuria
Rob A. Brodsky
Chapter 27 Pure Red Cell Aplasia
Emmanuel N. Dessypris
Part IV. RED BLOOD CELLS
Chapter 28 Pathobiology of the Human Erythrocyte and Its Hemoglobins
Martin H. Steinberg, Edward J. Benz, Jr., Henry Adewoye, and Ben Ebert
Chapter 29 Approach to Anemia in the Adult and Child
Peter Marks and Bertil Glader
Chapter 30 Anemia of Chronic Diseases
Lawrence B. Gardner and Edward J. Benz, Jr.
Chapter 31 Pathology of Iron Metabolism
Nancy C. Andrews
Chapter 32 Disorders of Iron Metabolism : Iron Deficiency and Overload
Gary M. Brittenham
Chapter 33 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
James S. Wiley and Michael R. Moore
Chapter 34 Megablastic Anemias
Aœok C. Anthony
Chapter 35 Thalassemia Syndromes
Bernard G. Forget and Alan R. Cohen
Chapter 36 Pathology of Sickle Cell Disease
Robert P. Hebbel
Chapter 37 Sickle Cell Disease
Stephen H. Embury, Elliot Vichinsky, and Yogen Saunthararajah
Chapter 38 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and
Methemoglobinemias
Edward J. Benz, Jr.
Chapter 39 Red Cell Enzymopathies
Xylina T. Gregg and Josef T. Prchal
Chapter 40 Red Cell Membrane Disorders
Patrick G. Gallagher and Petr Jarolim
Chapter 41 Autoimmune Hemolytic Anemias
Melody J. Cunningham and Leslie E. Silberstein
Chapter 42 Extrinsic Nonimmune Hemolytic Anemias
Stanley L. Schrier and Erin Gourley Reid
Part V. HOST DEFENSE AND ITS DISORDERS
Chapter 43 Complement Biology and Immunoglobulin
Gregory Kline, Robert Barrington, and Michael C. Carroll
Chapter 44 Normal Phagocyte Structure and Function
Robert L. Baehner
Chapter 45 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes
Steven J. Ackerman and Joseph H. Butterfield
Chapter 46 Disorders of Phagocyte Function and Number
Mary C. Dinauer and Thomas D. Coates
Chapter 47 Disorders of Lymphocyte Function
Aileen M. Cleary, Richard A. Insel, and David B. Lewis
Chapter 48 Histiocytic Disorders
Jeffrey M. Lipton and Robert J. Arceci
Chapter 49 Lysosomal Storage Diseases: Perspective and Principles
Gregory A. Grabowski and Nancy Leslie
Chapter 50 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
Stephen Gottschalk, Cliona M. Rooney, and Helen E. Heslop
Chapter 51 The Spleen and Its Disorders
Susan B. Shurin
Chapter 52 Basophils, Mast Cells, and Systemic Mastocytosis
Robert I. Parker and Dean D. Metcalfe
Part VI. HEMATOLOGIC MALIGNANCIES
Chapter 53 Conventional Cytogenetics and Molecular Cytogenetics in Hematological
Malignancies
Gordon Dewald and Rhett P. Ketterling
Chapter 54 The Molecular Basis of Neoplasia
Carol Westbrook
Chapter 55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
Stanton Gerson, Kapil N. Bhalla, Steven Grant, Richard Creeger, Nizar Bahlis
Chapter 56 Radiation Therapy in the Treatment of Hematologic Malignancies
Andrea K. Ng and Peter M. Mauch
Chapter 57 Clinical Use of Hematopoietic Growth Factors
Jacob M. Rowe and Irit Avivi
Chapter 58 Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma
Thomas E. Witzig
Chapter 59 Pathobiology of Acute Myeloid Leukemia
Brian Huntly and D. Gary Gilliland
Chapter 60 Clinical Manifestations of Acute Myeloid Leukemia
Kenneth B. Miller and Philip R. Daoust
Chapter 61 Therapy for Acute Myeloid Leukemia
Elihu H. Estey and Hagop Kantarijan
Chapter 62 Acute Myeloid Leukemia in Children
Gary V. Dahl and Howard J. Weinstein
Chapter 63 Pathobiology of Acute Lymphoblastic Leukemia
A. Thomas Look and Adolpho Ferrando
Chapter 64 Clinical Manifestations of Acute Lymphoblastic Leukemia
Stacey L. Berg, C. Philip Steuber, and David G. Poplack
Chapter 65 Treatment of Childhood Acute Lymphoblastic Leukemia
Lewis B. Silverman, Stephen E. Sallan, and Harvey J. Cohen
Chapter 66 Acute Lymphoblastic Leukemia in Adults
Dieter Hoelzer and Nicola Gokbudget
Chapter 67 Myelodysplastic Syndrome: Biology and Treatment
Richard Stone and Daniel DeAngelo
Chapter 68 Polycythemia Vera
Ronald Hoffman, Kelty R. Baker and Joe Prchal
Chapter 69 Chronic Myeloid Leukemia
Charles Sawyers and Neil P. Shah
Chapter 70 Myelofibrosis with Myeloid Metaplasia
Ronald Hoffman and Farhad Ravandi-Kashani
Chapter 71 Essential Thrombocythemia
Steven Fruchtman and Ronald Hoffman
Chapter 72 Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children
David M. Loeb, Robert P. Castleberry, and Cindy L. Schwartz
Chapter 73 Pathobiology of Non-Hodgkin Lymphomas
Gianluca Gaidano and Riccardo Dalla-Favera
Chapter 74 Patho-Biology of Hodgkin’s Lymphoma
Stefano A. Pileri, Brunangelo Falini and Harold Stein
Chapter 75 Hodgkin’s Disease: Clinical Manifestations, Staging, and Therapy
Volker Diehl, Daniel Re, and Andreas Josting
Chapter 76 The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas
Elaine Jaffe and Stefania Piltaluga
Chapter 77 Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma John G. Gribben and Ann S. La Casce
Chapter 78 Malignant Lymphomas in Childhood
John T. Sandlund, Jr.Michael P. Link
Chapter 79 Chronic Lymphocytic Leukemia
Dilip V. Patel and Kanti R. Rai
Chapter 80 Hairy Cell Leukemia
Annaadriana Zakanja, LoAnne C. Petersen, and Martin S. Tallman
Chapter 81 Cutaneous T-Cell Lymphomas
Timothy M. Kuzel, Joan Guitart, and Steven T. Rosen
Chapter 82 AIDS-Related Lymphomas
David T. Scadden
Chapter 83 Multiple Myeloma and Other Plasma Cell Disorders
Guido Tricot
Chapter 84 Immunoglobulin Light Chain Amyloidosis (Primary Amyloidosis, AL)
Morrie A. Gertz, Martha Q. Lacy, Angela Dispenzien
Chapter 85 Atypical Immune Lymphoproliferations
Timothy C. Greiner and Thomas G. Gross
Chapter 86 Clinical Approaches to Infections in the Compromised Host
Jo-Anne H. van Burik
Chapter 87 Nutritional Support of Patients with Hematologic Malignancies
Polly Lenssen and Saundra N. Aker
Chapter 88 Psychosocial Aspects of Hematologic Disorders
Ruth McCorkle, Siew Tzuh Tang, Jeannie Pasacreta
Chapter 89 Pain Management and Antiemetic Therapy in Hematologic Disorders
Janet L. Abrahm, Lauren Dias, and Bridget Fowler
Chapter 90 Palliative Care Janet L. Abrahm and Barbara Sourkes
Chapter 91 Indwelling Access Devices
Janet L. Abrahm and Linda M. Pellerin
Chapter 92 Late Complications of Hematologic Diseases and Their Therapies
Wendy Landier and Smita Bhatia
Part VII. TRANSPLANTATION
Chapter 93 Hematopoietic Stem Cell Transplantation for Acquired Nonmalignant Diseases and Myelodysplastic Syndrome
William Tse and H. Joachim Deeg
Chapter 94 Hematopoietic Cell Transplant for Immune Deficiences and Genetic Diseases
Stella M. Davies
Chapter 95 Results of Allogeneic Hematopoietic Cell Transplant for Hematologic Malignancies
Andrea Bacigalupo
Chapter 96 Autologous Transplant for Hematologic malignancies and Solio Tumors
Stephen J. Forman and Jeffery R. Schriber
Chapter 97 Unrelated Donor Stem Cell Transplantation Therapy
Effie W. Petersdorf and Claudio Anasetti
Chapter 98 Umbilical Cord Blood Transplantation
Juliet N. Barker and John E. Wagner
Chapter 99 Preparative Regimens for Hematopoietic Cell Transplantation
Marcos de Lima and Sergio Giralt
Chapter 100 Graft-versus-Host Disease and Graft-versus-Leukemia
Pavan Reddy and James L.M. Ferrara
Chapter 101 Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host Disease and Provide a Graft-versus-Tumor Effect
Catherine M. Bollard and Adrian P. Gee
Chapter 102 Gene Transfer for Hematologic Disorders
Katherine A. High and Malcolm K. Brenner
Chapter 103 Experimental Cell Therapy
Robert S. Negrin
Chapter 104 Complications After Hematopoietic Cell Transplantation
Daniel J. Weisdorf
Part VIII. HEMOSTASIS AND THROMBOSIS
Chapter 105 Megakaryocyte and Platelet Structure
Joseph E. Italiano and John Hartwig
Chapter 106 The Molecular Basis for Platelet Function
Edward F. Plow and Charles S. Abrams
Chapter 107 The Molecular Basis for Platelet Activation
Lawrence F. Brass
Chapter 108 The Blood Vessel Wall
Aly Karsan and John M. Harlan
Chapter 109 Molecular Basis of Blood Coagulation
Bruce Furie and Barbara C. Furie
Chapter 110 Molecular and Cellular Basis of Fibrinolysis
H. Roger Lijnen and Désiré Collen
Chapter 111 Regulatory Mechanisms in Hemostasis: Natural Anticoagulants
Charles T. Esmon
Chapter 112 Clinical Evaluation of Hemorrhagic Disorders: Bleeding History and Differential
Diagnosis of Pupura
Barry S. Coller and Paul I. Schniederman
Chapter 113 Laboratory Evaluation of Hemostatic Disorders
Jacob H. Rand and Lisa Senzel
Chapter 114 Structure, Biology, and Genetics of Factor VIII
Randal J. Kaufman and Stylianos E. Antonarakis
Chapter 115 Biochemistry of Factor IX and Molecular Biology of Hemophilia B
S. Jamie Freedman and Bruce Furie
Chapter 116 Clinical Aspects and Therapy of Hemophilia
Jay Nelson Lozier and Craig M. Kessler
Chapter 117 Inhibitors in Hemophilia
Donald I. Feinstein
Chapter 118 Other Clotting Factor Deficiencies
Harold R. Roberts and Miguel A. Escobar
Chapter 119 Disorders of Fibrinogen
José Martinez and Andres Ferber
Chapter 120 Structure, Biology, and Genetics of von Willebrand Factor
David Ginsburg and Denisa D. Wagner
Chapter 121 von Willebrand Disease: Clinical Aspects and Therapy
Gilbert C. White, II, and J. Evan Sadler
Chapter 122 Vitamin K: Metabolism and Disorders
Barbara C. Furie and Bruce Furie
Chapter 123 Inhibitors of Blood Coagulation
Donald I. Feinstein
Chapter 124 Disseminated Intrvascular Coagulation
Howard A. Liebman and Ilene C. Weitz
Chapter 125 Hemostatic Defects Associated with Dysproteinemias
Howard A. Liebman
Chapter 126 Disorders of Coagulation in the Neonate
Leonardo R. Brandao and Donna DiMichele
Chapter 127 Hypercoagulable States
Kenneth A. Bauer
Chapter 128 Venous Thromboembolism
Mark A. Crowther and Jeffrey S. Ginsberg
Chapter 129 Arterial Thromboembolism
Mark A. Crowther and Jeffrey S. Ginsberg
Chapter 130 Anticoagulation and Thrombolytic Therapy
Jeffrey I. Weitz
Chapter 131 Immune Thrombocytopenic Purpura, Neonatal Alloimmune
Thrombocytopenia, and Posttransfusion Purpura
James Bussel and Douglas Cines
Chapter 132 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome
Keith R. McCrae, J Evan Sadler, and Douglas Cines
Chapter 133 Thrombocytopenia Due to Platelet Destruction and Hypersplenism
Theodore E. Warkentin and John G. Kelton
Chapter 134 Hereditary Disorders of Platelet Function
Joel S. Bennett
Chapter 135 Acquired Disorders of Platelet Function
Jose Lopez and Perumal Thiagarajan
Part IX. TRANSFUSION MEDICINE
Chapter 136 Human Blood Group Anitgens and Antibodies
Part 1: Carbohydrate Determinants
Part 2: Protein Determinants
Marion E. Reid and Martin L. Olsson
Chapter 137 Human Platelet Antigens
Thomas J. Kunicki and Diane J. Nugent
Chapter 138 Human Leukocyte Antigen (HLA) and Human Neutrophil Antigen (HNA) Systems Ena Wang, Francesco M. Marincola, and David Stroncek
Chapter 139 Principles of Red Blood Cell Transfusion
Paul M. Ness and Margot S. Kruskall
Chapter 140 Principles of Platelet Transfusion Therapy
Thomas S. Kickler
Chapter 141 Principles of Neutrophil (Granulocyte) Transfusions
Ronald G. Strauss
Chapter 142 Transfusion of Plasma Derivatives: Fresh-Frozen Plasma,
Cryoprecipitate, Albumin, and Immunoglobulins
Cassandra D. Josephson and Christopher D. Hillyer
Chapter 143 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins
William N. Drohan and David B. Clark
Chapter 144 Transfusion Therapy for Coagulation factor Deficiencies
Catherine S. Manno and Peter Larson
Chapter 145 Hemapheresis and Cellular Therapy
Ellen F. Lazarus and Harvey G. Klein
Chapter 146 Practical Aspects of Stem Cell Collection
Scott D. Rowley, Stuart L. Goldberg, and Jack Hsu
Chapter 147 Transfusion Reactions
Edward L. Snyder and YanYun Wu
Chapter 148 Transfusion-Transmitted Diseases
Eberhard W. Fiebig, Michael P. Busch and Jay E. Menitove
Chapter 149 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation Richard M. Kaufman, Jerome Ritz and Walter H. Dzik
Chapter 150 Red Blood Cell Substitutes
Robert M. Winslow
Part X. CONSULTATIVE HEMATOLOGY
Chapter 151 Hematologic Manifestations of Systemic Disease: Liver and Renal Disease
Rachel Rosovsky and Peter W. Marks
Chapter 152 Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, and Cancer
Peter W. Marks and David S. Rosenthal
Chapter 153 Hematologic Manifestations of AIDS
David H. Henry and James A. Hoxie
Chapter 154 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
Mark T. Reding and Nigel S. Key
Chapter 155 Hematologic Aspects of Pregnancy
Edward J. Benz, Jr.
Chapter 156 Hematologic Manifestations of Childhood Illness
A. Kim Ritchey and Frank G. Keller
Part XI. SPECIAL TESTS AND PROCEDURES
Chapter 157 Bone Marrow Examination
Daniel H. Ryan and Harvey J. Cohen
Chapter 158 Automated Analysis of Blood Cells
Raymond E. Felgar and Daniel H. Ryan
Chapter 159 Laboratory Detection of Hemoglobinopathies and Thalassemias
Martin H. Steinberg and David Chui
Chapter 160 Antenatal Diagnosis of Hematologic Disorders
Kim Kramer and Harvey J. Cohen
Chapter 161 Use of Molecular Techniques in the Analysis of Hematologic Diseases
Michele Paessler and Adam Bagg
Chapter 162 Molecular Imaging in Hematology
Francis G. Blankenberg
Appendix Normal Blood Values: Selected Reference Values for Neonatal, Pediatric, and Adult Populations
Sharon M. Geaghan
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